Title

Associationbetweenstatinuseandosteoporoticfractureinpatientswithchronicobstructivepulmonarydisease:apopulation-based,matchedcase-controlstudy

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Background/背景

Intherecentyears,chronicobstructivepulmonarydisease(COPD)hasbeenfoundtobeassociatedwithahigherriskofnew-onsetosteoporoticfracture(NOF).However,theexistenceofsuchanassociationintheCOPDpatientsreceivingstatintreatmentremainsunknown.ThepresentstudyaimedtoinvestigatetheassociationbetweenCOPDandNOFinstatin-treatedpatients.

近年来，发现慢性阻塞性肺疾病（COPD）与新发骨质疏松性骨折(NOF)的高风险相关。但是这种关联在接受他汀类药物治疗的COPD患者中，尚不清楚。本研究旨在调查COPD患者使用他汀类药物与骨质疏松性骨折之间的关联。

Methods/方法

Thepresentstudywasconductedoveraperiodof10years(JanuarytoDecember)inTaiwan.COPDpatientsreceivingstatintreatmentwereincludedinthestatinusergroup,whereastherandomlyselectedstatinnon-users,with1:1matchingforsex,age,indexdate,andCharlsonComorbidityIndex,wereincludedinthestatinnon-usergroup.Thehazardratio(HR)ofNOFsinCOPDpatientswasestimatedbetweenstatinuserandnonusergroups.

这是一项在台湾地区进行的为期10年(年1月至年12月)的研究，按照性别、年龄、指数日期和Charlson共病指数随机按1:1匹配：将接受他汀类药物治疗的COPD患者纳入他汀类药物使用组，非他汀类药物使用组。并在他汀类药物使用组和非使用组之间对COPD患者NOFs的危险比(HR)进行了评估。

Results/结果

Atotalof86,caseswereidentifiedasthestatin-treatedpatients,and86,subjectswereincludedinthecontrolgroupofstatinnon-users.Initially,theriskofNOFwasfoundtobehigheramongthestatinusersas